HIV Medication Storage: How to Keep Your Treatment Safe and Effective

When you’re taking HIV medication, drugs like tenofovir, efavirenz, or dolutegravir that suppress the virus and keep your immune system strong. Also known as antiretrovirals, these pills only work if they’re stored correctly. A pill that’s too hot, too cold, or too damp can lose its strength—or turn harmful. You don’t need a lab to keep your meds safe. You just need to know the basics.

Most HIV drugs are designed to stay stable at room temperature, usually between 68°F and 77°F. But that doesn’t mean leaving them on the windowsill or in the bathroom cabinet. Heat and moisture are the two biggest enemies. If you live somewhere hot and humid, like Florida or Texas, your medicine can break down faster than you think. Sunlight? Even worse. Some antiretrovirals, like certain formulations of raltegravir or atazanavir, can degrade in just a few weeks if exposed to direct light. And never, ever store them in the fridge unless the label says so. Freezing can crack the pills or change how your body absorbs them. One study from the CDC found that improperly stored HIV meds led to detectable viral loads in patients who thought they were doing everything right.

What about travel? If you’re flying or driving across the country, keep your meds in your carry-on. Checked baggage can sit in freezing cargo holds or bake in hot airport tarmacs. A small insulated bag with a cool pack (not frozen) works better than a plastic bag on the seat. And always keep them in their original bottles. Those labels have expiration dates, lot numbers, and storage instructions that pharmacists and doctors need to see. If you transfer pills to a pill organizer, make sure it’s dry and dark—and never leave it in a hot car. Even a few hours in 90°F heat can damage your treatment.

And don’t forget about pets and kids. HIV medications look like regular pills. A curious child or a dog that finds a dropped tablet can end up in the ER. Store your meds out of reach, ideally in a locked box or high cabinet. It’s not just about safety—it’s about keeping your treatment effective. If your meds lose potency, the virus can bounce back, resist drugs, and become harder to treat.

Below, you’ll find real-world guides on how to handle specific HIV drugs, what to do if your meds get too hot, how to tell if they’ve gone bad, and how to store them during power outages or emergencies. These aren’t theoretical tips. They come from people who’ve lived with HIV for years and learned the hard way what works—and what doesn’t.