Tag: CYP2D6 inhibition

Tamoxifen and SSRIs: What Really Happens to Cancer Outcomes When They're Used Together

Tamoxifen and SSRIs can interact, reducing the active cancer-fighting metabolite endoxifen. But does that actually increase cancer recurrence? Evidence from large studies shows mixed results - and most experts now say antidepressant choice should focus on patient needs, not enzyme theory.